Macromolecule-Small Molecule Interactions (I)
نویسندگان
چکیده
منابع مشابه
Small-molecule inhibitors of protein-protein interactions.
Protein-protein interactions regulate almost all aspects of cellular signaling and aberrant protein-protein interactions have the potential to cause or contribute to human disease. The modulation of these interactions by drug-like molecules would offer previously unavailable opportunities to explore the relevance of pre-selected protein-protein interactions for cellular signaling, as well as be...
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INTRODUCTION Advances in NMR technology over the last 20 years have made information on solution structures of proteins increasingly available. High-resolution solution structures of proteins as large as 20-25 kDa are tractable in most cases, and recent advances allowed Kay to solve the structure of an 82 kDa protein. These advances in NMR analysis of protein structure have made possible the st...
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BACKGROUND AND PURPOSE We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using short echo time in vivo proton MR spectroscopy. METHODS Single-voxel spectra with TE=22 ms were obtained with and without inversion recovery suppression of small-molecule resona...
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Title of Document: Applications of Small Molecule-Carbon Nanotube Interactions Jarrett Delano Leeds, Doctor of Philosophy 2014 Co-Directed By: Professor YuHuang Wang Department of Chemistry and Biochemistry The interactions of single-walled carbon nanotubes (SWNTs) with small molecules are critical to harnessing their remarkable electronic properties. Due to quenching effects, properties such a...
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Activation of the p53 pathway has been considered a therapeutic strategy to target cancers. We have previously identified several p53-activating small molecules in a cell-based screen. Two of the compounds activated p53 by causing DNA damage, but this modality was absent in the other four. We recently showed that one of these, BMH-21, inhibits RNA polymerase I (Pol I) transcription, causes the ...
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ژورنال
عنوان ژورنال: Sen-ito Kogyo
سال: 1972
ISSN: 1884-2275
DOI: 10.2115/fiber1968.5.256